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Stinging Nettle Root

ProstateHormonesSHBG

Modulates SHBG (sex hormone binding globulin) — making more free testosterone bioavailable. Also a moderate prostate herb (often combined with saw palmetto).

EvidenceModerate

Moderate for BPH urinary symptoms, free testosterone elevation via SHBG binding. Effects: 4–12 weeks.

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Reference dose

120–360 mg/day standardised extract, or 4–6 g/day root.

Choose a stack first, or enter your own amount here. Reference information is not a personal prescription.

Urtica dioica root (distinct from the leaf, which has different uses) contains lignans and lectins that bind to SHBG, freeing testosterone from its carrier protein and increasing the bioavailable / free fraction. Used clinically in Germany for benign prostatic hyperplasia (BPH) — improves urinary symptoms comparable to mild medications. Often combined with saw palmetto for prostate stacks; on its own for men trying to free up bound testosterone.

Form
Standardised nettle root extract. Often combined with saw palmetto and pygeum in prostate formulas.
Timing
With food. Often split.
Schedule
Daily.
Side effects
Generally well-tolerated. Mild GI upset, allergic reactions rare.
Interactions
Antihypertensives — possible additive (mild diuretic effect). Diabetes medications — mild glucose effects. Lithium — diuretic effect can alter levels.
Contraindications
Pregnancy. Hormone-sensitive cancers (relative — hormonal modulation).
Lab markers
Total + free testosterone, SHBG. PSA, IPSS for BPH.
Food sources
Nettle leaf is edible (cooked / dried — raw nettle stings). The root is the medicinal part used in supplements.

Pairs with

Saw palmetto, pygeum, beta-sitosterol (prostate stack). Tongkat ali for men's hormone support combos.

Where to buy

Life Extension
Ultra Prostate Formula (with Nettle Root)
175 mg nettle root (in blend) × 30 softgels
$26.33
$0.878 / dose
Blend formula — saw palmetto + nettle + pygeum + lycopene. Not pure nettle.
Curated pick
Nature's Way Nettle Root
Thorne and PE don't carry nettle root standalone. Standalone alternatives: Nature's Way Nettle Root, Gaia Herbs Nettle Root, Eclectic Institute Nettle Root.

Prices are checked periodically and drift — Amazon’s is the live one. We take no commission on these links.

within Herbs & botanicals