Curated Stacks
Stacks.
Explore ten curated stacks with ingredients, reference doses, timing and the reasoning behind each one. Read freely; create an account when you want to save and personalise a stack.
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Showing 10 of 10 curated stacks
For — Everyone, every day
The Foundational Stack
The five supplements with the strongest evidence for broad benefit at the lowest cost. If you take nothing else, take these. About $2/day for all five. Start here. Layer everything else on top.
DurationDaily — foreverCost est~$2/day
Read the long-form take: If I had to pick five supplements forever →
For — Sharp focus on demand
The Morning Focus Stack
Caffeine alone is jittery; caffeine + L-theanine is smooth alertness. Add L-tyrosine for stress-resistant focus and rhodiola for sustained mental endurance. Skip on weekends to avoid tolerance — this is a work-days stack, not a daily one.
DurationWorkdays only — 5 on / 2 offSkip ifYou're anxious or on SSRIs
For — Better sleep depth and architecture
The Deep Sleep Stack
Foundational minerals and amino acids plus a GABA modulator. Together they support every phase of sleep without the morning grog of pharmaceutical sedatives or high-dose melatonin. Expect 7–10 days for the full effect to settle in.
DurationDailyPair withCool room (17°C), no screens after 9pm
Read the long-form take: If I had to fix my sleep tonight →
For — Chronic stress with the "wired but tired" pattern
The Wired-but-Tired Reset Stack
The modern stress signature: too much cortisol all day, dysregulated cortisol at night, can't switch off but can't get sharp either. Adaptogens during the day, cortisol-lowering at night, magnesium to support GABA receptors. Eight weeks usually resets the cortisol rhythm.
Duration8–12 weeks then reassessCautionDon't stack with thyroid medication without medical input
Read the long-form take: If I had to manage chronic stress without medication →
For — Rebuilding gut flora after antibiotics
The Post-Antibiotic Recovery Stack
A course of antibiotics wipes out beneficial gut bacteria along with the bad. S. boulardii is a yeast probiotic that survives antibiotics (bacterial probiotics don't) and outcompetes C. difficile. L-glutamine rebuilds the gut lining. Multistrain probiotic + prebiotic fibre repopulate and feed the recovery. 4–6 weeks gets most users back to baseline.
DurationThrough antibiotic course + 2–4 weeks afterTipBuy Florastor (the patented S. boulardii)
Read the long-form take: If I had to rebuild my gut →
For — PMS, perimenopause, and hormonal balance
The Perimenopause Foundation Stack
Addresses the most common patterns: estrogen metabolism, progesterone modulation, cycle-related mood and inflammation. Pairs with the full Perimenopause Protocol guide for the complete picture — sleep, training, hormone testing, and HRT considerations. The optional oxytocin add-on is an experiment, not a foundation — the Oxytocin guide explains why, and how to give it a fair trial.
The Stack — 6 supplements
Optional add-on — prescription, after the foundations
DurationDaily; reassess at 8–12 weeksFor severe symptomsTalk to a doctor about HRTOxytocinOff-label, compounded; never in pregnancy. Read the guide first.
For — Post-40 joint maintenance and mild OA
The Joint Protection Stack
UC-II trains your immune system not to attack cartilage — small dose (40mg), real effect. Collagen peptides provide the building blocks for cartilage and tendon repair. Curcumin (Meriva form, not raw turmeric) blunts inflammation. Omega-3 is the systemic background. Lifting heavy with good form does more than any supplement — this stack supports the training, not replaces it.
DurationDaily; evaluate at 12 weeksNot forTorn meniscus or advanced OA (get imaging)
Long-form: If I had to keep my joints moving past 50 →
For — Long-term brain protection
The Cognitive Longevity Stack
The cognitive supplements with the most-replicated human data. Creatine for ATP. Omega-3 (DHA-heavy) for membrane integrity. Lion's Mane for nerve growth factor. Bacopa for memory consolidation (slow — takes 8–12 weeks). Choline for acetylcholine synthesis. Cardiovascular fitness is the single best cognitive intervention known — this stack supports it, not substitutes for it.
DurationDaily; expect 8–12 weeks for measurable changeBonusAdd NMN or NR if budget allows
For — Staying well through cold and flu season
The Immune Fortress Stack
Two layers: a daily prevention base (D3, zinc, vitamin C) and an acute toolkit for the first sign of a cold (elderberry, zinc lozenges, NAC). The two are different stacks for different moments — the daily layer runs all winter; the acute layer kicks in within hours of symptoms.
Daily layer — through cold season
DurationDaily layer through winter; acute layer 5–7 daysSkipElderberry for autoimmune disease
For — Post-drinking, post-Tylenol, or general liver support
The Liver Reset Stack
NAC is the glutathione precursor — used in hospitals to treat acetaminophen overdose. Milk thistle and TUDCA support liver cell membranes and bile flow. Sulforaphane activates Nrf2, the genetic switch that turns on the body's own detox machinery. This isn't a "detox cleanse" — your liver does detox continuously. This stack gives it the cofactors it needs.
Duration4–8 weeks acute reset; daily if you drink regularlyThe real fixStop drinking; NAFLD is reversible in 6–12 months
Long-form: If I had to support my liver through life →
These are recipes, not prescriptions. Each stack is an opinionated combination based on published evidence and editorial judgment. Doses are typical starting points — not personalised to your bloodwork, medications, or conditions. Talk to a doctor before starting anything new, especially if you're pregnant, on prescription medication, or managing a diagnosed condition. Click any supplement above for its full entry — contraindications, interactions, and side effects all live there.