Systemic Inflammation Response Index (SIRI)
Specialistalso —
What it isA newer composite combining monocytes, neutrophils, and lymphocytes to capture systemic inflammation.
DoesIndexes innate inflammation against adaptive competence.
GoodA low SIRI signals quiescent inflammation and a healthy immune system.
BadElevated SIRI predicts mortality in cardiovascular disease, cancer, and chronic illness.
- Standard
- Lab-specific.
- Optimal
- 0.3–0.9 (lower is good)
- Modifiers
- Rises with chronic inflammation and infection.
How to optimize
- Lifestyle
- Sleep, stress management, resistance training, quit smoking.
- Diet
- Mediterranean pattern; cut ultra-processed food.
- Supplements
- Omega-3 EPA+DHA (2–4g/day), curcumin (500mg 2×/day).
- Peptides
- Thymosin alpha-1.
- Drugs
- Treat underlying cause.
Thymosin Alpha-1Omega-3 (EPA/DHA)Curcumin (Turmeric)
Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.
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