← Blood tests
Systemic Immune-Inflammation Index (SII)
Specialistalso —
What it isA calculated composite using platelets, neutrophils, and lymphocytes that captures inflammation and immune balance in one number.
DoesIntegrates three independent prognostic markers into a stronger composite predictor.
GoodA low SII signals balanced immune-inflammatory tone and tracks better outcomes across diseases.
BadElevated SII predicts mortality in cancer, cardiovascular disease, and chronic inflammation.
- Standard
- Lab-specific.
- Optimal
- 200–450 (lower is good)
- Modifiers
- Rises with infection, stress, smoking.
How to optimize
- Lifestyle
- Sleep, stress management, resistance training, quit smoking.
- Diet
- Mediterranean pattern; cut ultra-processed food.
- Supplements
- Omega-3 EPA+DHA (2–4g/day), curcumin (500mg 2×/day).
- Peptides
- Thymosin alpha-1.
- Drugs
- Treat underlying cause.
Thymosin Alpha-1Omega-3 (EPA/DHA)Curcumin (Turmeric)
Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.
within Blood Cells