Immunoglobulins (IgG, IgA, IgM, IgE — total)
Advanced wellnessalso —
What it isThe major classes of antibodies produced by B cells and plasma cells. Each class plays a distinct immune role.
DoesIgG provides long-term immunity and crosses the placenta; IgA defends mucosal surfaces; IgM is the first responder to new antigens; IgE drives allergic reactions and antiparasite immunity.
GoodMid-range immunoglobulins signal balanced humoral immunity.
BadLow immunoglobulins flag immunodeficiency and increase infection risk. High IgE indicates allergy or parasitic infection. Monoclonal spikes suggest plasma cell disorders.
- Standard
- IgG 700–1600 mg/dL; IgA 70–400; IgM 40–230; IgE <100 IU/mL.
- Optimal
- IgG 1000–1400, IgA 150–350, IgM 60–180, IgE <30 IU/mL (narrow target)
- Modifiers
- Vary with age and infections.
How to optimize
- Lifestyle
- Sleep, stress management.
- Diet
- Mediterranean pattern; adequate protein.
- Supplements
- Vitamin D3 (target 60–80 ng/mL), zinc, vitamin C; colostrum for IgA support.
- Peptides
- Thymosin alpha-1, thymalin for immune support.
- Drugs
- IV immunoglobulin replacement for primary immunodeficiency.
Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.
within Autoimmune