Anti-Intrinsic Factor
Specialistalso —
What it isAutoantibodies that block intrinsic factor — the stomach-made protein required for B12 absorption in the ileum.
DoesCauses pernicious anemia by preventing B12 absorption regardless of dietary intake.
GoodNegative result rules out classical pernicious anemia.
BadPositive anti-intrinsic factor confirms pernicious anemia and indicates lifelong B12 supplementation or injections are needed.
- Standard
- Negative.
- Optimal
- Negative (lower is good)
- Modifiers
- Persists indefinitely.
How to optimize
- Lifestyle
- —
- Diet
- Cannot meet B12 needs orally if absorption blocked.
- Supplements
- High-dose oral B12 (1000–2000µg/day) or sublingual; some require injections.
- Peptides
- —
- Drugs
- B12 (cyanocobalamin or hydroxocobalamin) injections.
Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.
within Autoimmune