← Blood tests
Anti-Scl-70
Specialistalso topoisomerase i antibody
What it isAutoantibodies targeting topoisomerase I (Scl-70), associated with diffuse cutaneous systemic sclerosis.
DoesMarks the diffuse, more aggressive form of systemic sclerosis.
GoodNegative result in someone with skin changes argues against diffuse scleroderma.
BadPositive anti-Scl-70 identifies diffuse scleroderma and predicts interstitial lung disease and progressive internal organ involvement.
- Standard
- Negative.
- Optimal
- Negative (lower is good)
- Modifiers
- Stable over time.
How to optimize
- Lifestyle
- Quit smoking.
- Diet
- —
- Supplements
- —
- Peptides
- —
- Drugs
- Mycophenolate, cyclophosphamide, nintedanib, rituximab for systemic sclerosis with lung involvement.
Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.
within Autoimmune