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17-Hydroxyprogesterone (17-OHP)
Specialistalso —
What it isA steroid intermediate in the pathway from cholesterol to cortisol and androgens. Adrenals and ovaries both produce it.
DoesActs as a marker of adrenal steroid biosynthesis and a screening tool for enzyme deficiencies.
GoodCycle-appropriate 17-OHP signals normal adrenal and ovarian steroid biosynthesis.
BadElevated 17-OHP suggests congenital adrenal hyperplasia (especially non-classical 21-hydroxylase deficiency) or PCOS.
- Standard
- Follicular <80 ng/dL; luteal <285.
- Optimal
- 20–80 ng/dL follicular (narrow target)
- Modifiers
- Cycle phase; rises with adrenal stimulation.
How to optimize
- Lifestyle
- Stress management.
- Diet
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- Supplements
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- Peptides
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- Drugs
- Glucocorticoid replacement in classical congenital adrenal hyperplasia.
Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.
within Women's Hormones