Semax

Russian ACTH(4-10)-derived heptapeptide studied as a fast-acting nootropic and BDNF elevator.

Semax is a Russian-developed fragment of the ACTH hormone, stripped of its hormonal action so only the brain effects remain. It's a genuine prescription drug there — for stroke recovery, cognitive complaints, and attention — and works largely by raising BDNF, the protein that helps neurons grow and form new connections. Users describe a clean lift in focus, verbal fluency, and mental stamina without the jittery edge of stimulants. It's taken intranasally so it reaches the brain quickly, with effects inside an hour.

Dose

300–1000 mcg intranasal daily.

Reconstitute

10 mg + 2 mL = 5 mg/mL. Intranasal in a dropper or spray bottle.

Schedule

10–30 day cycles, 2–3× per year.

Half-life

~30 minutes (base Semax).

Timing

AM.

Risks

Minimal. Rare headache or insomnia at high doses.

Educational reference — not medical advice. Many peptides are not approved for the uses discussed; verify status in your jurisdiction and decide anything here with a qualified clinician.

within Cognitive & Neurological