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TSH Receptor Antibody (TRAb / TSI)
Specialistalso thyroid stimulating immunoglobulin
What it isAutoantibodies that bind and activate the TSH receptor on thyroid cells, mimicking TSH and driving uncontrolled thyroid hormone production.
DoesDrive the autoimmune hyperthyroidism of Graves' disease.
GoodAbsent antibodies signal no Graves' disease.
BadElevated TRAb confirms Graves' disease; very high levels suggest more severe or longer-lasting disease and predict relapse after treatment.
- Standard
- <1.75 IU/L.
- Optimal
- 0–1.0 IU/L (lower is good)
- Modifiers
- Can rise transiently during pregnancy in those with prior Graves' disease.
How to optimize
- Lifestyle
- Quit smoking (worsens thyroid eye disease); stress management.
- Diet
- Adequate selenium; anti-inflammatory pattern.
- Supplements
- Selenium (200µg/day, especially for thyroid eye disease).
- Peptides
- —
- Drugs
- Methimazole, propylthiouracil, radioactive iodine, thyroidectomy; teprotumumab for thyroid eye disease. --
Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.
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