Triglyceride–Glucose (TyG) Index

Advanced wellness

also tyg

What it isA calculated index combining fasting triglycerides and fasting glucose into a single number. Because it doesn't require an insulin assay, it's available from any standard panel.

DoesEstimates insulin resistance using two cheap, ubiquitous markers.

GoodA low TyG score signals strong insulin sensitivity — clean carbohydrate handling without an excess triglyceride load.

BadA high TyG score predicts diabetes, fatty liver, heart attack, stroke, and all-cause mortality. It often flags risk before A1c moves.

Standard: <4.5 normal.
Optimal: 3.5–4.2 (lower is good)
Modifiers: Rises with weight gain, alcohol, refined carbs; falls with weight loss and exercise.

How to optimize

Lifestyle: Resistance training, Zone 2 cardio 150+ minutes/week, sleep 7–9 hours.
Diet: Cut sugar, refined grains, and alcohol. Build meals around protein, vegetables, and whole-food fats.
Supplements: Berberine (500mg 3×/day), omega-3 EPA+DHA (2–4g/day), inositol (2g 2×/day).
Peptides: GLP-1 agonists (semaglutide, tirzepatide, retatrutide) drop both inputs.
Drugs: Metformin, GLP-1 agonists, SGLT2 inhibitors, fibrates.

Omega-3 (EPA/DHA)SemaglutideTirzepatideRetatrutideBerberineInositol (Myo / D-Chiro)

Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.

within Blood Sugar & Metabolic