SDMA (Symmetric Dimethylarginine)
Specialistalso —
What it isA structural isomer of ADMA released during protein turnover. Unlike ADMA, it doesn't directly inhibit nitric oxide synthase, and the kidneys clear it almost entirely.
DoesActs as a sensitive marker of kidney filtration and, indirectly, endothelial health.
GoodLow SDMA tracks intact kidney and undamaged endothelium.
BadElevated SDMA signals early kidney dysfunction and predicts cardiovascular mortality.
- Standard
- <140 ng/mL.
- Optimal
- 50–110 ng/mL (lower is good)
- Modifiers
- Rises predictably with declining kidney.
How to optimize
- Lifestyle
- Hydration, manage blood pressure, avoid nephrotoxins (chronic NSAIDs), Zone 2 cardio.
- Diet
- Moderate protein, plenty of vegetables, low salt; Mediterranean pattern.
- Supplements
- Omega-3 EPA+DHA (2–4g/day), CoQ10 (100–200mg/day).
- Peptides
- —
- Drugs
- ACE inhibitors, ARBs, SGLT2 inhibitors protect kidney and indirectly lower SDMA.
Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.
within Cardiovascular & BP