Plasma Renin Activity
Specialistalso pra
What it isAn enzyme released by specialized kidney cells when they sense low blood pressure or low sodium. It cleaves angiotensinogen to start the renin-angiotensin-aldosterone cascade.
DoesInitiates aldosterone release, vasoconstriction, and sodium retention.
GoodA mid-range renin alongside appropriate aldosterone signals balanced volume regulation.
BadSuppressed renin with high aldosterone signals primary aldosteronism. High renin signals dehydration, kidney artery stenosis, or appropriate response to drugs.
- Standard
- Upright 0.65–5 ng/mL/hr.
- Optimal
- 1.0–3.0 ng/mL/hr upright (narrow target)
- Modifiers
- Posture-dependent; affected by many blood pressure medications.
How to optimize
- Lifestyle
- Manage blood pressure.
- Diet
- Moderate sodium.
- Supplements
- —
- Peptides
- —
- Drugs
- ACE inhibitors, ARBs, direct renin inhibitors. --
Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.
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