Estrone (E1)

Specialist

also —

What it isEstrone is a weaker estrogen produced primarily by aromatase in fat tissue. After menopause, when ovarian estradiol drops, estrone becomes the dominant circulating estrogen.

DoesProvides background estrogenic activity, particularly important in postmenopausal women.

GoodMid-range estrone signals balanced adipose estrogen production.

BadHigh estrone can drive endometrial hyperplasia and breast cancer risk in postmenopausal women with excess body fat. Very low estrone in postmenopause contributes to bone loss.

Standard: Premenopausal 17–200; postmenopausal 7–40 pg/mL.
Optimal: 40–120 pg/mL premenopausal, 20–40 pg/mL postmenopausal (narrow target)
Modifiers: Tracks body fat; rises with aromatase activity.

How to optimize

Lifestyle: Maintain healthy body composition through resistance training and Zone 2 cardio.
Diet: Mediterranean pattern; cruciferous vegetables (broccoli, kale, brussels sprouts); flax.
Supplements: DIM (200mg/day), calcium-D-glucarate (500mg 2×/day).
Peptides: —
Drugs: Aromatase inhibitors in selected postmenopausal contexts.

Calcium D-GlucarateCalcium

Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.

within Women's Hormones