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Cockcroft-Gault Creatinine Clearance
Specialistalso crcl
What it isAn older equation estimating kidney filtration from creatinine, age, weight, and sex. Drug dosing labels still use it for many medications.
DoesProvides the historical reference for renal drug dose adjustment.
GoodA high value confirms adequate filtration capacity for handling renally cleared drugs.
BadLow values trigger dose reductions for many medications to prevent toxicity.
- Standard
- >90 mL/min.
- Optimal
- 95–140 mL/min (higher is good)
- Modifiers
- Same as creatinine.
How to optimize
- Lifestyle
- Same levers as eGFR.
- Diet
- Moderate protein.
- Supplements
- —
- Peptides
- —
- Drugs
- ACE inhibitors, ARBs, SGLT2 inhibitors for protection; renal-cleared drugs may need dose adjustment. --
Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.
within Kidney