← Blood tests
Anti-Smith (Sm)
Specialistalso —
What it isAutoantibodies that target Smith nuclear ribonucleoprotein, one of the most specific markers for systemic lupus.
DoesConfirms lupus diagnosis when positive.
GoodNegative excludes one specific lupus marker but doesn't rule out the disease.
BadPositive anti-Sm is highly specific for lupus and supports diagnosis even when ANA pattern is ambiguous.
- Standard
- Negative.
- Optimal
- Negative (lower is good)
- Modifiers
- Stable over time, less variable than dsDNA.
How to optimize
- Lifestyle
- Sun protection; stress management.
- Diet
- Mediterranean pattern.
- Supplements
- Omega-3 EPA+DHA (2–4g/day), vitamin D3.
- Peptides
- —
- Drugs
- Hydroxychloroquine, immunosuppressants for lupus.
Omega-3 (EPA/DHA)Vitamin D3
Reference ranges are general adult lab norms; optimal ranges are editorial picks from the longevity literature — not medical advice. Always interpret results with your physician.
within Autoimmune