Ipamorelin
GHRP — SelectiveSelective GHRP that triggers a clean GH pulse without spiking cortisol, prolactin, or hunger.
Ipamorelin tells your pituitary to release a pulse of your own growth hormone by mimicking ghrelin at the GH-secretagogue receptor. What made it the community favourite is its selectivity: older GHRPs also dragged up cortisol (stress) and prolactin and switched on hunger, whereas Ipamorelin does almost none of that. You get the deeper sleep, faster recovery, and slow body-composition improvement of a GH bump without the side baggage. It's the "clean" half of the standard GH stack and the one most people start with.
- Dose
- 200–300 mcg subQ per dose, 1–3× daily.
- Reconstitute
- 10 mg + 2 mL = 5 mg/mL. 6 units = 300 mcg.
- Schedule
- 5 days on / 2 off, 12–16 week blocks.
- Half-life
- ~2 hours.
- Timing
- Pre-bed (best — aligns with natural GH pulse), or post-workout, or AM fasted. Not within ~2 hours of food — insulin blunts the response.
- Risks
- Mild flushing/tingling on first doses for some. Long-term GH elevation in non-deficient adults is debated.
Educational reference — not medical advice. Many peptides are not approved for the uses discussed; verify status in your jurisdiction and decide anything here with a qualified clinician.
within Growth Hormone — Natural Release (Secretagogues)