FOXO4-DRI

Senolytic peptide that disrupts FOXO4–p53 binding, selectively triggering apoptosis in senescent cells.

As you age, some cells stop dividing but refuse to die — these "zombie" (senescent) cells linger and pump out inflammatory signals that age the tissue around them. FOXO4-DRI is a senolytic: it breaks a protein interaction keeping those zombie cells alive, nudging them to self-destruct while leaving healthy cells untouched. In mice the results were dramatic — restored fur, fitness, and kidney function. In humans it's almost entirely untested, expensive, and used in pulsed protocols, so it remains a research tool rather than a wellness staple.

Dose

5 mg IV or IP over a 3-day pulse, every other day.

Reconstitute

10 mg + 1 mL = 10 mg/mL.

Schedule

Pulsed every 2–3 months (mimicking dasatinib + quercetin senolytic protocols).

Half-life

~24 hours.

Timing

Anytime.

Educational reference — not medical advice. Many peptides are not approved for the uses discussed; verify status in your jurisdiction and decide anything here with a qualified clinician.

within Longevity & Anti-Aging