Myeloperoxidase (MPO)

Specialist

also —

What it isMPO is an enzyme released by activated neutrophils and macrophages, including those infiltrating vulnerable arterial plaque. It produces reactive oxidants that damage the vessel wall.

DoesOxidizes LDL, consumes nitric oxide, and degrades the protective fibrous cap covering atherosclerotic plaque.

GoodLow MPO indicates quiescent vascular inflammation and stable plaque biology.

BadElevated MPO signals active plaque inflammation and instability, predicting near-term cardiac events independently of LDL or hsCRP.

Standard

<470 pmol/L.

Optimal

100–300 pmol/L (lower is good)

Modifiers

Rises in acute coronary syndrome, infection, and chronic inflammation.

How to optimize

Lifestyle: Quit smoking, weight loss, Zone 2 cardio, stress management.
Diet: Mediterranean pattern; cut ultra-processed food, refined carbs, seed oils; emphasize polyphenol-rich foods (berries, olive oil, dark leafy greens, green tea).
Supplements: Omega-3 EPA+DHA (2–4g/day), curcumin (500mg 2×/day), polyphenols (resveratrol, quercetin), vitamin E (mixed tocopherols, 200 IU/day).
Peptides: —
Drugs: Statins lower MPO modestly via anti-inflammatory effects.

within Cardiovascular & BP