Fibrinogen

Advanced wellness

also factor i

What it isFibrinogen is a soluble plasma protein made by the liver that is converted to fibrin during clot formation. It also functions as an acute-phase reactant that rises with inflammation.

DoesForms the structural scaffold of blood clots; contributes to blood viscosity.

GoodA mid-range level provides adequate clotting capacity without thrombotic excess.

BadHigh fibrinogen increases blood viscosity and clot risk, predicting heart attack, stroke, and venous thromboembolism. It also reflects chronic systemic inflammation.

Standard

200–400 mg/dL.

Optimal

200–280 mg/dL (lower is good within range)

Modifiers

Rises with smoking, obesity, stress, infection, pregnancy.

How to optimize

Lifestyle: Quit smoking, regular aerobic exercise, weight loss, stress management.
Diet: Mediterranean pattern; cut ultra-processed food; add fatty fish, olive oil.
Supplements: Omega-3 EPA+DHA (2–4g/day), curcumin (500mg 2×/day), nattokinase (2000 FU/day), vitamin E (mixed tocopherols, 200 IU/day).
Peptides: —
Drugs: Fibrates lower fibrinogen modestly; statins reduce it through anti-inflammatory effect.

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