Lp-PLA2

Specialist

also lipoprotein-associated phospholipase a2, plac test

What it isLp-PLA2 is an enzyme bound predominantly to LDL particles. It hydrolyzes oxidized phospholipids and generates pro-inflammatory mediators inside arterial plaque.

DoesDrives vessel-wall inflammation specifically, distinguishing arterial inflammation from systemic.

GoodLow Lp-PLA2 indicates a low-inflammation plaque environment.

BadElevated Lp-PLA2 predicts cardiovascular events, especially ischemic stroke, and tracks arterial inflammation more specifically than hsCRP.

Standard

<225 nmol/min/mL.

Optimal

100–180 nmol/min/mL (lower is good)

Modifiers

Tracks LDL particle count; falls with statins.

How to optimize

Lifestyle: Zone 2 cardio, weight loss, smoking cessation.
Diet: Mediterranean pattern; cut saturated fat, refined carbs, seed oils; emphasize fatty fish and olive oil.
Supplements: Omega-3 EPA+DHA (2–4g/day), curcumin (500mg 2×/day), niacin (under supervision).
Peptides: —
Drugs: Statins lower Lp-PLA2 substantially; niacin and fibrates also help.

within Cardiovascular & BP