AST (Aspartate Aminotransferase)

Routine annual

also sgot

What it isAST is an enzyme found in liver, heart, skeletal muscle, kidney, and red blood cells. Like ALT, it catalyzes an amino acid metabolism step and leaks into the bloodstream when its host cells are damaged.

DoesReports cell injury — but from any of several tissues, not just liver.

GoodLow AST signals healthy liver and muscle without ongoing damage.

BadElevated AST flags liver disease, muscle injury, cardiac damage, or hemolysis. When AST rises higher than ALT, alcoholic liver disease is the leading suspect.

Standard
8–48 U/L.
Optimal
10–22 U/L (lower is good)
Modifiers
Rises briefly with intense exercise and muscle injury (rhabdomyolysis); rises in alcohol use.

How to optimize

Lifestyle
Resistance training and Zone 2 cardio for visceral fat; eliminate alcohol; avoid excessive endurance exercise without recovery.
Diet
Cut fructose, refined carbs, seed oils, alcohol; Mediterranean pattern.
Supplements
Berberine (500mg 3×/day), N-acetylcysteine (600mg 2×/day), choline (500mg/day), milk thistle silymarin (200mg 3×/day).
Peptides
GLP-1 agonists.
Drugs
GLP-1 agonists, pioglitazone; resmetirom for NASH.