ALT (Alanine Aminotransferase)

Routine annual

also sgpt

What it isALT is an enzyme concentrated inside hepatocytes — liver cells — that catalyzes a key step in amino acid metabolism. When liver cells are damaged, ALT leaks into the bloodstream.

DoesActs as the most specific blood marker of liver cell injury.

GoodLow ALT signals healthy hepatocytes and minimal liver stress.

BadElevated ALT marks fatty liver, viral hepatitis, alcohol injury, drug toxicity, and ischemic damage. Even mildly elevated ALT predicts metabolic disease and mortality.

Standard

Men 7–55 U/L; women 7–45 U/L.

Optimal

10–22 U/L men, 10–18 U/L women (lower is good)

Modifiers

Rises briefly with intense exercise; muscle injury contributes; alcohol and acetaminophen are common offenders.

How to optimize

Lifestyle: Lose visceral fat through resistance training and Zone 2 cardio; eliminate alcohol; quit smoking.
Diet: Cut fructose, refined carbs, and seed oils — the dominant fatty-liver drivers. Mediterranean pattern, lean protein, fibrous vegetables; intermittent fasting helps fatty liver.
Supplements: Berberine (500mg 3×/day), choline (500mg/day), N-acetylcysteine (600mg 2×/day), omega-3 EPA+DHA (2–4g/day), milk thistle silymarin (200mg 3×/day), vitamin E (200 IU/day in NAFLD).
Peptides: GLP-1 agonists (semaglutide, tirzepatide, retatrutide) reverse fatty liver substantially.
Drugs: GLP-1 agonists, pioglitazone, vitamin E (for NASH); resmetirom for advanced NASH.

within Liver & Detox