Anti-Scl-70

Specialist

also topoisomerase i antibody

What it isAutoantibodies targeting topoisomerase I (Scl-70), associated with diffuse cutaneous systemic sclerosis.

DoesMarks the diffuse, more aggressive form of systemic sclerosis.

GoodNegative result in someone with skin changes argues against diffuse scleroderma.

BadPositive anti-Scl-70 identifies diffuse scleroderma and predicts interstitial lung disease and progressive internal organ involvement.

Standard
Negative.
Optimal
Negative (lower is good)
Modifiers
Stable over time.

How to optimize

Lifestyle
Quit smoking.
Diet
Supplements
Peptides
Drugs
Mycophenolate, cyclophosphamide, nintedanib, rituximab for systemic sclerosis with lung involvement.