Tissue Transglutaminase IgA (tTG-IgA)

Routine annual

also celiac antibody

What it isAutoantibodies targeting tissue transglutaminase, the enzyme that modifies gluten peptides in the gut. tTG-IgA is the primary blood screen for celiac disease.

DoesMarks active celiac disease in someone consuming gluten.

GoodNegative tTG-IgA in someone consuming gluten effectively rules out celiac disease (assuming IgA isn't deficient).

BadPositive tTG-IgA strongly suggests celiac disease and prompts biopsy confirmation; remains positive while celiac is untreated.

Standard

<4 U/mL.

Optimal

0–4 U/mL (lower is good)

Modifiers

Gluten-free diet normalizes the antibody — must be eating gluten for the test to be valid; check total IgA to rule out deficiency.

How to optimize

Lifestyle: Strict gluten avoidance if celiac confirmed.
Diet: Gluten-free diet is the only effective treatment for celiac disease.
Supplements: Address nutrient deficiencies common in celiac (iron, B12, folate, vitamin D, zinc).
Peptides: BPC-157 supports gut healing.
Drugs: —

within Autoimmune