Anti-Centromere

Specialist

also —

What it isAutoantibodies targeting centromere proteins during cell division. Highly associated with limited systemic sclerosis (CREST syndrome).

DoesMarks limited cutaneous systemic sclerosis.

GoodNegative result in someone with Raynaud's or skin tightening argues against limited scleroderma.

BadPositive anti-centromere identifies limited scleroderma and predicts pulmonary hypertension as a major complication.

Standard

Negative.

Optimal

Negative (lower is good)

Modifiers

Stable over time.

How to optimize

Lifestyle: Cold protection for Raynaud's; quit smoking.
Diet: —
Supplements: Omega-3 EPA+DHA (2–4g/day) may help vascular tone.
Peptides: —
Drugs: Calcium channel blockers for Raynaud's; treatment of pulmonary hypertension if present.

within Autoimmune