Anti-dsDNA

Specialist

also double-stranded dna antibody

What it isAutoantibodies that target double-stranded DNA, found primarily in systemic lupus erythematosus.

DoesMarks lupus with high specificity and correlates with disease activity, particularly kidney involvement.

GoodNegative anti-dsDNA in someone with positive ANA argues against active SLE.

BadElevated anti-dsDNA confirms lupus and rising titers predict flares, especially renal involvement.

Standard

<30 IU/mL.

Optimal

0–30 IU/mL (lower is good)

Modifiers

Fluctuates with disease activity.

How to optimize

Lifestyle: Sun protection; stress management; quit smoking.
Diet: Mediterranean pattern; identify food sensitivities.
Supplements: Omega-3 EPA+DHA (2–4g/day), curcumin, vitamin D3, DHEA in some lupus patients with monitoring.
Peptides: —
Drugs: Hydroxychloroquine, immunosuppressants, biologics (belimumab, anifrolumab).

within Autoimmune