Anti-CCP (Cyclic Citrullinated Peptide)

Advanced wellness

also acpa

What it isAnti-citrullinated protein antibodies target proteins that have undergone citrullination — a post-translational modification.

DoesMarks rheumatoid arthritis with high specificity.

GoodA negative anti-CCP largely rules out rheumatoid arthritis.

BadPositive anti-CCP confirms rheumatoid arthritis, often before clinical disease appears, and predicts more aggressive disease and joint erosion.

Standard
<20 U/mL.
Optimal
0–20 U/mL (lower is good)
Modifiers
Smoking strongly drives anti-CCP positivity in genetically susceptible individuals; periodontal disease may contribute.

How to optimize

Lifestyle
Quit smoking; oral hygiene; anti-inflammatory lifestyle.
Diet
Mediterranean pattern; identify food sensitivities.
Supplements
Omega-3 EPA+DHA (2–4g/day), curcumin, vitamin D3.
Peptides
BPC-157, thymosin alpha-1.
Drugs
Methotrexate, biologics for confirmed RA.