Humanin

Mitochondrial-derived 24-residue peptide that protects neurons and improves insulin sensitivity.

Humanin belongs to a small class of peptides encoded not in the cell's main DNA but inside the mitochondria themselves — tiny signals the powerhouses send out to protect the body under stress. It guards neurons against the kind of damage seen in Alzheimer's, improves insulin sensitivity, and protects heart tissue in models; levels naturally decline with age, tracking with rising disease risk. It's an emerging longevity option built around mitochondrial resilience, and pairs conceptually with MOTS-C, the other mitochondrial-derived peptide.