FOXO4-DRI

Senolytic peptide that disrupts FOXO4–p53 binding, selectively triggering apoptosis in senescent cells.

As you age, some cells stop dividing but refuse to die — these "zombie" (senescent) cells linger and pump out inflammatory signals that age the tissue around them. FOXO4-DRI is a senolytic: it breaks a protein interaction keeping those zombie cells alive, nudging them to self-destruct while leaving healthy cells untouched. In mice the results were dramatic — restored fur, fitness, and kidney function. In humans it's almost entirely untested, expensive, and used in pulsed protocols, so it remains a research tool rather than a wellness staple.