Cagrilintide

Long-acting amylin analog — extends GLP-1 effects via additional satiety and gastric-emptying signals.

Cagrilintide copies amylin, a second satiety hormone the pancreas releases alongside insulin — a different "you're full" pathway from GLP-1. On its own it's a decent appetite suppressant, but its real role is as a multiplier: stacked with a GLP-1 drug it deepens the weight loss and often softens the nausea, because two satiety signals let you get more effect at a lower GLP dose. That's the logic behind CagriSema (with Semaglutide) and the researched Retatrutide and Tirzepatide combos.