Steroids: a great bridge, a poor home
- Fast but costly
Glucocorticoids (prednisone) work within days — far faster than methotrexate's 6–12 weeks — so they're an excellent short 'bridge' while a DMARD takes hold, and for calming flares (an injection into a single flaring joint avoids whole-body exposure). But long-term use carries a heavy toll: osteoporosis, diabetes, weight gain, infection, and more. The rule is lowest dose, shortest time; guidelines advise strongly against staying on them for months. Evidence ●●●●○