Systemic Inflammation Response Index (SIRI)

Specialist

also

What it isA newer composite combining monocytes, neutrophils, and lymphocytes to capture systemic inflammation.

DoesIndexes innate inflammation against adaptive competence.

GoodA low SIRI signals quiescent inflammation and a healthy immune system.

BadElevated SIRI predicts mortality in cardiovascular disease, cancer, and chronic illness.

Standard
Lab-specific.
Optimal
0.3–0.9 (lower is good)
Modifiers
Rises with chronic inflammation and infection.

How to optimize

Lifestyle
Sleep, stress management, resistance training, quit smoking.
Diet
Mediterranean pattern; cut ultra-processed food.
Supplements
Omega-3 EPA+DHA (2–4g/day), curcumin (500mg 2×/day).
Peptides
Thymosin alpha-1.
Drugs
Treat underlying cause.