Immunoglobulins (IgG, IgA, IgM, IgE — total)

Advanced wellness

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What it isThe major classes of antibodies produced by B cells and plasma cells. Each class plays a distinct immune role.

DoesIgG provides long-term immunity and crosses the placenta; IgA defends mucosal surfaces; IgM is the first responder to new antigens; IgE drives allergic reactions and antiparasite immunity.

GoodMid-range immunoglobulins signal balanced humoral immunity.

BadLow immunoglobulins flag immunodeficiency and increase infection risk. High IgE indicates allergy or parasitic infection. Monoclonal spikes suggest plasma cell disorders.

Standard

IgG 700–1600 mg/dL; IgA 70–400; IgM 40–230; IgE <100 IU/mL.

Optimal

IgG 1000–1400, IgA 150–350, IgM 60–180, IgE <30 IU/mL (narrow target)

Modifiers

Vary with age and infections.

How to optimize

Lifestyle: Sleep, stress management.
Diet: Mediterranean pattern; adequate protein.
Supplements: Vitamin D3 (target 60–80 ng/mL), zinc, vitamin C; colostrum for IgA support.
Peptides: Thymosin alpha-1, thymalin for immune support.
Drugs: IV immunoglobulin replacement for primary immunodeficiency.

within Autoimmune