IgG Subclasses (1–4)

Specialist

also —

What it isIgG comes in four subclasses (IgG1, 2, 3, 4) that differ in. IgG1 and IgG3 fight viruses; IgG2 fights encapsulated bacteria; IgG4 modulates allergic responses.

DoesProvides nuanced view of humoral immunity beyond total IgG.

GoodBalanced subclass distribution signals robust humoral immunity.

BadSelective subclass deficiency (especially IgG2 or IgG3) can cause recurrent infections despite normal total IgG. Elevated IgG4 marks IgG4-related disease.

Standard

Subclass-specific.

Optimal

Mid-range per subclass (narrow target)

Modifiers

Age-dependent reference ranges.

How to optimize

Lifestyle: Sleep, stress.
Diet: Mediterranean pattern.
Supplements: Vitamin D3, zinc.
Peptides: Thymosin alpha-1.
Drugs: IV immunoglobulin in selected deficiencies; immunosuppressants for IgG4-related disease. --

within Autoimmune