Free T3 / Reverse T3 Ratio

Specialist

also

What it isA ratio that captures the balance between active T3 production and inactive rT3 diversion in peripheral tissues.

DoesIndexes functional thyroid status at the tissue level — what's actually getting through to receptors.

GoodA high ratio signals strong active thyroid hormone availability and a metabolism running smoothly.

BadA low ratio indicates impaired conversion and tracks fatigue, weight gain, cognitive sluggishness, and chronic stress states.

Standard
No standard cutoff.
Optimal
0.25–0.40 (higher is good)
Modifiers
Same as Free T3 and reverse T3.

How to optimize

Lifestyle
Adequate calories, sleep, stress management; avoid overtraining.
Diet
Adequate calories and carbs; iron, selenium, zinc.
Supplements
Selenium (200µg/day), zinc (15–30mg/day), iron if deficient.
Peptides
Drugs
Liothyronine in selected patients.