Estrone (E1)

Specialist

also —

What it isEstrone is a weaker estrogen produced primarily by aromatase in fat tissue. After menopause, when ovarian estradiol drops, estrone becomes the dominant circulating estrogen.

DoesProvides background estrogenic activity, particularly important in postmenopausal women.

GoodMid-range estrone signals balanced adipose estrogen production.

BadHigh estrone can drive endometrial hyperplasia and breast cancer risk in postmenopausal women with excess body fat. Very low estrone in postmenopause contributes to bone loss.

Standard

Premenopausal 17–200; postmenopausal 7–40 pg/mL.

Optimal

40–120 pg/mL premenopausal, 20–40 pg/mL postmenopausal (narrow target)

Modifiers

Tracks body fat; rises with aromatase activity.

How to optimize

Lifestyle: Maintain healthy body composition through resistance training and Zone 2 cardio.
Diet: Mediterranean pattern; cruciferous vegetables (broccoli, kale, brussels sprouts); flax.
Supplements: DIM (200mg/day), calcium-D-glucarate (500mg 2×/day).
Peptides: —
Drugs: Aromatase inhibitors in selected postmenopausal contexts.

within Women's Hormones