Estradiol, Ultrasensitive

Specialist

also —

What it isA higher-sensitivity estradiol assay (typically mass spectrometry) accurate at the low concentrations found in postmenopausal women, men, and children.

DoesProvides accurate measurement when standard E2 assays read at the floor of their dynamic range.

GoodCycle-appropriate or HRT-target levels signal adequate estrogen action.

BadFalsely high readings from standard assays at low concentrations mislead postmenopausal HRT dosing.

Standard

Lab-specific.

Optimal

60–120 pg/mL on HRT postmenopausal; 20–35 pg/mL men (narrow target)

Modifiers

Use this assay whenever measuring low E2 levels.

How to optimize

Lifestyle: Resistance training, sleep, weight management.
Diet: Mediterranean pattern; cruciferous vegetables.
Supplements: DIM, calcium-D-glucarate, vitamin D3.
Peptides: —
Drugs: Estradiol replacement; aromatase inhibitors in men with elevated E2.

within Women's Hormones