Cockcroft-Gault Creatinine Clearance

Specialist

also crcl

What it isAn older equation estimating kidney filtration from creatinine, age, weight, and sex. Drug dosing labels still use it for many medications.

DoesProvides the historical reference for renal drug dose adjustment.

GoodA high value confirms adequate filtration capacity for handling renally cleared drugs.

BadLow values trigger dose reductions for many medications to prevent toxicity.

Standard
>90 mL/min.
Optimal
95–140 mL/min (higher is good)
Modifiers
Same as creatinine.

How to optimize

Lifestyle
Same levers as eGFR.
Diet
Moderate protein.
Supplements
Peptides
Drugs
ACE inhibitors, ARBs, SGLT2 inhibitors for protection; renal-cleared drugs may need dose adjustment. --