Cardio IQ Lipoprotein Fractionation (Ion Mobility)

Advanced wellness

also ion mobility lipoprotein profile

What it isA lab technique that separates lipoprotein particles by size and charge in the gas phase, reporting concentrations of each LDL, HDL, and VLDL subfraction. Provides a particle-level view that complements standard cholesterol numbers.

DoesQuantifies the size distribution of LDL particles (large buoyant vs small dense), HDL subfractions, and VLDL remnants, giving a more granular cardiovascular risk picture.

GoodA profile dominated by large, buoyant LDL and large HDL with low small dense LDL and low VLDL remnants reflects favorable particle biology and low atherogenic risk.

BadA predominance of small dense LDL with low large HDL flags atherogenic dyslipidemia, often driven by insulin resistance, central adiposity, and high triglycerides. This pattern raises cardiovascular event risk independent of LDL-C.

Standard

Subfraction-specific concentration ranges (lab dependent).

Optimal

Predominantly large LDL pattern, small dense LDL <20% of total, large HDL elevated (higher is good for large subclass dominance)

Modifiers

Fasting status, recent illness, hormone therapy, weight change, and recent intense exercise shift the profile.

How to optimize

Lifestyle: Zone 2 cardio 3–4 hours weekly, strength training, weight loss in the overweight, sleep, smoking cessation.
Diet: Cut refined carbohydrates and ultra-processed food; emphasize fiber, monounsaturated and omega-3 fats; modest carbohydrate restriction often shifts pattern toward large LDL.
Supplements: Omega-3 EPA+DHA 2–4 g/day, niacin (with monitoring), berberine 500 mg twice daily, plant sterols.
Peptides: Tirzepatide, semaglutide, AOD-9604 in selected metabolic contexts.
Drugs: Statin, ezetimibe, PCSK9 inhibitors; bempedoic acid; fibrates when triglyceride-driven.

within Other