Atherogenic Index of Plasma (AIP)

Advanced wellness

also aip

What it isA calculated log ratio of triglycerides to HDL cholesterol that compresses small dense LDL prediction into a single number without requiring particle-size testing.

DoesEstimates the atherogenic burden of the lipid profile by leveraging the strong correlation between elevated TG/HDL and small dense LDL.

GoodA low AIP signals a lipid profile dominated by large buoyant LDL and low cardiovascular risk.

BadA high AIP captures the atherogenic dyslipidemia of metabolic syndrome — small dense LDL, low HDL, elevated remnants.

Standard
<0.11 low risk; 0.11–0.21 medium; >0.21 high.
Optimal
−0.3 to 0.0 (lower is good)
Modifiers
Same as TG/HDL ratio.

How to optimize

Lifestyle
Zone 2 cardio, resistance training, weight loss, cut alcohol.
Diet
Cut sugar, refined grains, alcohol; Mediterranean or low-carb patterns.
Supplements
Omega-3 EPA+DHA (2–4g/day), berberine (500mg 3×/day).
Peptides
GLP-1 agonists.
Drugs
Statins, fibrates, GLP-1 agonists.