Apolipoprotein A1 (ApoA1)

Advanced wellness

also apo a-i

What it isApoA1 is the principal structural protein of HDL particles. Counting ApoA1 effectively counts HDL particles and reflects the capacity of the reverse cholesterol transport system.

DoesForms HDL, accepts cholesterol efflux from cells, and triggers the enzyme that matures HDL particles.

GoodHigh ApoA1 indicates a robust reverse-transport system and tracks lower cardiovascular event rates. The ApoB/ApoA1 ratio is a stronger predictor than either alone.

BadLow ApoA1 signals impaired cholesterol clearance and metabolic syndrome.

Standard

Men >120 mg/dL; women >140 mg/dL.

Optimal

150–180 mg/dL men, 170–200 mg/dL women (higher is good); ApoB/ApoA1 ratio 0.3–0.5

Modifiers

Women run higher; rises with estrogen and alcohol.

How to optimize

Lifestyle: Aerobic exercise, weight loss in those with excess fat, quit smoking.
Diet: Olive oil, fatty fish, nuts; cut refined carbs and trans fats.
Supplements: Omega-3 EPA+DHA (2–4g/day), niacin (under supervision).
Peptides: —
Drugs: Limited pharmacologic tools — niacin and fibrates modestly raise ApoA1.

within Cholesterol & Lipids