DMAE (Dimethylaminoethanol)
An amine that the brain uses to support acetylcholine production. Cult-status nootropic from the 1970s; modest cognitive effects and some skin-firming evidence topically.
Limited modern evidence. Older trials suggested cognitive support, ADHD adjunct, mood. Topical DMAE has some skin-firming RCT support. Effects: 4–8 weeks.
DMAE is a tertiary amine present in trace amounts in some fish (and synthesised in small amounts by the brain). It's a precursor to choline and supports acetylcholine production. Oral DMAE was studied in the 1970s–80s as a nootropic / antidepressant (under the trade name Deaner) with mixed results — modest cognitive effects, anti-aging claims, mood support. Modern use is more often topical for skin firmness (Perricone-style serums). Oral cognitive evidence is moderate at best.
- Form
- DMAE bitartrate capsules. Topical DMAE in firming serums.
- Dose
- Oral: 100–300 mg/day. Topical: per product.
- Timing
- AM with food. Mildly activating.
- Schedule
- Daily, often cycled (5 on, 2 off).
- Side effects
- Headache, insomnia, irritability, muscle tension at higher doses.
- Interactions
- Cholinergic medications — additive. Sedatives — opposing.
- Contraindications
- Bipolar disorder. Epilepsy (theoretical seizure-threshold concerns). Pregnancy / breastfeeding (animal teratogenicity concerns at high doses).
- Lab markers
- Not standard.
- Food sources
- Trace amounts in sardines, anchovies, salmon.
Pairs with
Alpha-GPC, citicoline (choline / acetylcholine stack). Topical retinoids, vitamin C for skin combos.
within Bioactive amines & polyamines