Artichoke Leaf Extract
Stimulates bile flow and helps with functional indigestion, especially fat-related. Modest cholesterol-lowering effects too.
Moderate for functional dyspepsia, IBS-C, LDL reduction. Effects: meals (digestive) to 6–12 weeks (lipids).
Cynara scolymus leaf extract (different from the edible head) contains cynarin and chlorogenic acid, which stimulate bile production and flow from the liver and gallbladder. The German Commission E approves it for dyspepsia. Best evidence: post-meal indigestion (especially after fatty meals), modest LDL cholesterol reduction (~7%), and bloating / IBS-C symptoms. Often combined with ginger or peppermint for digestive blends.
- Form
- Standardised artichoke leaf extract to 13–18% caffeoylquinic acids (Cynara, ArtichOK).
- Dose
- 320–640 mg 2–3x daily with meals.
- Timing
- With meals — most effective taken right before eating.
- Schedule
- Daily, or with problematic meals.
- Side effects
- Generally well-tolerated. Mild GI upset, gas, headache. Allergic reactions in those allergic to Asteraceae family.
- Interactions
- Bile acid sequestrants — opposing. Generally clean otherwise.
- Contraindications
- Bile duct obstruction. Active gallstones (relative). Asteraceae allergy. Pregnancy (limited data).
- Lab markers
- Lipid panel if used for cholesterol. LFTs if monitoring liver.
- Food sources
- Edible artichokes themselves provide some of the same compounds but at much lower doses than leaf extract.
Pairs with
Milk thistle, dandelion, TUDCA (liver / bile stack). Peppermint (Iberogast-style digestive combos).
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