SLU-PP-332

Pan-ERR agonist studied as "exercise in a pill" — mitochondrial biogenesis and endurance signaling.

SLU-PP-332 activates the ERR family of receptors, which govern how many mitochondria a cell builds and how strongly it shifts toward fat-burning, endurance-type metabolism. In mice it pushed the body to make more mitochondria and improved running endurance with no actual exercise — the headline "exercise in a pill" result. It's strictly preclinical for now, taken orally, with essentially no human safety data, so it sits in the speculative tier.