NAD+

Coenzyme

Critical redox coenzyme and sirtuin/PARP substrate — fuel for mitochondrial and DNA-repair machinery.

NAD+ is a coenzyme every cell needs to turn food into energy — and it's also the raw material your longevity enzymes (sirtuins) and DNA-repair crews (PARPs) burn through to do their jobs. Levels fall steeply with age, so those repair and energy systems effectively run short on fuel. Topping it up (injected or IV) aims to restore cellular energy, support DNA repair, and may carry anti-aging benefits. Fair warning: it stings going subQ, and an IV push that's too fast causes flushing and chest pressure — a slow drip is mandatory.

Dose

50–100 mg subQ daily, or 250–500 mg slow IV 1–2× per week.

Reconstitute

1000 mg + 5 mL = 200 mg/mL. 25 units = 50 mg.

Schedule

10–30 day loads, then 1–2× weekly maintenance.

Half-life

Minutes in plasma; cellular pool lasts much longer.

Timing

AM — it's energizing.

Risks

SubQ injections sting noticeably. IV doses can cause flushing, nausea, chest pressure — slow drip mandatory.

Pairs withGlutathione (NAD+ + GSH pack — energy + antioxidant defense).

within Metabolic & Mitochondrial