LL-37

Antimicrobial

LL-37 is a potent, naturally occurring antimicrobial peptide that serves as the "heavy artillery" for your innate immune system.

It works by physically puncturing the cell walls of harmful bacteria, fungi, and viruses, while simultaneously dissolving the protective biofilms that chronic pathogens use to hide from your white blood cells. A healthy optimizer would run a short, two-week cycle twice a year to perform a "biological deep clean" — pruning the gut microbiome of pro-inflammatory bacteria and clearing out any dormant, low-grade infections that may be subtly draining the nervous system. This "pulse" approach ensures your internal environment remains pristine and your immune system stays sharp without the risk of over-stimulation or chronic inflammation associated with long-term use.

Dose

100–200 mcg daily.

Reconstitute

5 mg + 2.5 mL = 2 mg/mL. 5 units = 100 mcg.

Schedule

2-week pulse, twice a year. Do not run long-term.

Half-life

Short.

Timing

AM. Avoid pre-bed (immune activation).

Risks

Pro-inflammatory at high doses — can flare autoimmune conditions. Histamine release possible. Start low.

Pairs withDon't take LL-37 and ARA-290 at the same time — they send opposing immune signals. Run them as a "Clean and Repair" sequence: LL-37 first to clean out pathogens, then ARA-290 to repair and quiet the nervous system.

within Inflammation & Gut