Kisspeptin

HPG Axis

Hypothalamic neuropeptide that triggers GnRH release — restores natural sex-hormone signaling upstream.

Kisspeptin sits at the very top of the hormone chain — it's the signal that tells your brain to kick off the whole cascade that ends in testosterone (or estrogen) production. Instead of replacing a hormone, it restarts your own factory from upstream, which is why it's used to restore natural testosterone, support fertility, and recover the HPG axis after it's been suppressed (e.g., post-cycle). It also lifts libido without the melanocortin side effects of the tanning peptides — a cleaner "switch the system back on" approach.

Dose
100–300 mcg subQ daily.
Reconstitute
10 mg + 2 mL = 5 mg/mL. 4 units = 200 mcg.
Schedule
4–8 week cycles, especially during or after HPG suppression.
Half-life
~30 minutes.
Timing
AM.
Risks
Minimal. Transient receptor desensitization at very high doses.
Pairs withEnclomiphene for full HPG restoration; common post-cycle protocol.

within Sexual Health & Reproductive