Vitamin D Receptor (VDR) genotype

Specialist

also vdr snps (foki, bsmi, taqi, apai)

What it isGenotyping of common single-nucleotide polymorphisms in the vitamin D receptor gene that modestly affect receptor and downstream calcium, immune, and bone signaling. Most clinical impact is small at the individual level despite enthusiast attention.

DoesModulates how efficiently a given 25-OH vitamin D level translates into receptor-driven gene expression.

GoodFunctionally favorable VDR variants give robust signaling at moderate vitamin D levels.

BadReduced- variants have weak associations with osteoporosis, autoimmune disease, certain cancers, and infection susceptibility. Effects are modest; serum 25-OH vitamin D, calcium, and PTH remain better treatment targets than genotype.

Standard

Genotype reported per SNP.

Optimal

No widely-accepted optimal — the genotype is fixed; the goal is maintaining 25-OH vitamin D in the optimal range with normal calcium and PTH regardless of variant.

Modifiers

One-time test; genotype does not change.

How to optimize

Lifestyle: Sun exposure adequate for skin type and latitude; weight-bearing exercise for bone; avoid smoking.
Diet: Vitamin D-rich foods (fatty fish, egg yolks, fortified products), adequate calcium and magnesium.
Supplements: Vitamin D3 typically 2000–5000 IU/day titrated to 25-OH level 50–80 ng/mL; vitamin K2 (MK-7) 100–200 µg/day; magnesium glycinate 200–400 mg/day.
Peptides: —
Drugs: —

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