SDMA (Symmetric Dimethylarginine)

Specialist

also —

What it isA structural isomer of ADMA released during protein turnover. Unlike ADMA, it doesn't directly inhibit nitric oxide synthase, and the kidneys clear it almost entirely.

DoesActs as a sensitive marker of kidney filtration and, indirectly, endothelial health.

GoodLow SDMA tracks intact kidney and undamaged endothelium.

BadElevated SDMA signals early kidney dysfunction and predicts cardiovascular mortality.

Standard

<140 ng/mL.

Optimal

50–110 ng/mL (lower is good)

Modifiers

Rises predictably with declining kidney.

How to optimize

Lifestyle: Hydration, manage blood pressure, avoid nephrotoxins (chronic NSAIDs), Zone 2 cardio.
Diet: Moderate protein, plenty of vegetables, low salt; Mediterranean pattern.
Supplements: Omega-3 EPA+DHA (2–4g/day), CoQ10 (100–200mg/day).
Peptides: —
Drugs: ACE inhibitors, ARBs, SGLT2 inhibitors protect kidney and indirectly lower SDMA.

within Cardiovascular & BP